Tuhin K Sinha, Sheerin Khatib-Shahidi, Thomas E Yankeelov, Khubaib Mapara, Moneeb Ehtesham5, Shannon Cornett, Benoit M Dawant, Richard M Caprioli, John C Gore
Nature Methods 2008, 5, 57-59
We have developed a method for integrating three dimensional–volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
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