MALDI MSI resolution limit in biological samples

[Bård Smedsrød]

I wonder if anybody out there knows how far down in resolution it is possible to go using MALDI MSI. My interest would be to study tissue sections of normal and pathologic human tissue. Does the technology allow resolution down to single cells? Can it be taken even further down – to localize the presence of molecules inside of individual cells – and even in organelles?
Regards,
Bard

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Bard Smedsrod
Professor and Head of Vascular Biology Research Group (uit.no/research/vbrg)
Scientific head of Laboratory for Electron Microscopy (uit.no/forskning/em)
Department of Medical Biology
University of Tromso
NO-9037 Tromso
NORWAY
tel.: +47-77644687 / +47-99599463
email: bard.smedsrod@uit.no
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[Saira]

With the latest advancements in the instrumentation, it is now possible to use the resolution of upto 10µm.

[Author]

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