How about modification to the laser optics on the DE-STR. I have heard that one needs to change and/or modify the prism to get a tighter beam on to the MALDI plate.
Any pointers you may have will be helpful.
Hm, I would guess that one would have to make more changes to the optics than replacing the prism (e.g. set a lense closer to the target, open the beam up and then refocus it again). Bernhard Spengler published his superb optics for the LAMMA 2000 – could give you some ideas.
Thanks for your note. I will look into the article you mentioned. That said, I also take comfort in the fact that you have been able to use your STR without any changes. We may decide to upgrade to a faster laser and digitizer similar to your instrument.
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