MALDI imaging mass spectrometry: molecular snapshots of biochemical systems

mouse epididymisDale S Cornett, Michelle L Reyzer, Pierre Chaurand & Richard M Caprioli
Nat. Meth. 2007, 4, pp. 828-833

Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is emerging as a powerful tool for investigating the distribution of molecules within biological systems through the direct analysis of thin tissue sections. Unique among imaging methods, MALDI-IMS can determine the distribution of hundreds of unknown compounds in a single measurement. We discuss the current state of the art of MALDI-IMS along with some recent applications and technological developments that illustrate not only its current capabilities but also the future potential of the technique to provide a better understanding of the underlying molecular mechanisms of biological processes.

http://dx.doi.org/10.1038/nmeth1094

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